Ana-Maria Lennon devotes her research to dendritic cells, the "sentinels" of our immune system. She is particularly interested in how these cells move during their "patrols" in the body.
Ana-Maria Lennon is an Inserm Research Director and is in charge of the Spatio-temporal regulation of antigen presentation and cell migration* team at the Institut Curie (Paris). She seeks to understand how dendritic cells act when patrolling the body and raise the alarm when they discover a threat.
The researcher's work with her team has revealed that these sentinel cells can move in two different ways. When they patrol, they do it "intermittently": they move, stop and start again. But when a dendritic cell has discovered an intruder, "swallowed" it and headed to the nearest ganglion to trigger an immune response, there is no time to lose. Its movement becomes unidirectional and fast.
*Inserm unit 932/Paris Descartes University/ Institut Curie