A report from the Centre d’immunologie de Marseille-Luminy (CIML, Center of Immunology Marseille-Luminy). From worm to man, from molecules to the whole organism, from physiology to pathology, researchers at the CIML study all areas of immunology.
Whoa, is that a creature from outer space? Not exactly. It is from the Centre d’immunologie de Marseille-Luminy (CIML), directed by Philippe Pierre who has taken the helm from Éric Vivier. More specifically, it is from one of their powerful microscopes, the aptly-named “light sheet microscope”. And, so as not to keep you in suspense any longer, it is a mouse embryo, fixed for all eternity by the use of laser beams! But what for? For the purpose of studying innate lymphoid cells, a specific type of immune cell that combines the characteristics of T cells, adaptive immune cells, and innate immune cells.
Serge Van de Pavert, author of the photo, and his team are researching a subtype of these cells involved in the development of secondary lymphoid organs (such as the spleen and lymph nodes), sites of transit, accumulation, and meeting of immune cells and antigens recognized by antibodies. From the embryonic stage, their formation and differentiation can be modified by changing certain dietary factors. The purpose of this 3D imaging with immunofluorescent labeling is therefore to analyze the number and distribution of the cells involved in building the lymphatic system, which is essential for tissue drainage, the circulation of nutrients, hormones, and white blood cells, for immune system function and for healing.
From worm to man, from molecules to the whole organism, from physiology to pathology, the CIML and its 14 teams address all areas of contemporary immunology: the genesis of numerous cell populations, their modes of differentiation and activation, their involvement in cancer, infectious and inflammatory diseases, and the mechanisms of cell death.
Find the report in issue 39 of Science&Santé magazine