A report from the Mouse Clinical Institute in Illkirch, near Strasbourg. Join the mouse on its journey through the various investigation departments.
The MCI is aptly named. Located in Illkirch, near Strasbourg, the Mouse Clinical Institute* is a research infrastructure of the Institute of Genetics and of Molecular and Cell Biology (IGBMC) exclusively dedicated to the production and characterization of mice. Directed by Yann Hérault since 2010, the 6,200 m2 MCI has departments that are not unlike those found in a hospital for human beings.
With its departments of cardiac, respiratory, metabolic, and cognitive investigation, to name but a few… the MCI is an actual clinic for mice! Why? Because the objective of its researchers is to describe every aspect of mice which are either entrusted to them by other (private or public) laboratories or which they themselves produce. And also because, as one of the 18 research institutions that make up the International Mouse Phenotyping Consortium (IMPC), the MCI is participating in a major project to explore the consequences of the mutation of each one of 20,000 mouse genes. The MCI's role in the project is to produce, using CRISPR/Cas9 technology (among others), 235 mouse lines – each of which must be studied. It has an additional parallel objective, which is to identify drug candidates using mouse models of various diseases. Join the mouse on its journey through the various investigation departments.
*Inserm/CNRS/Université de Strasbourg Unit 964